Glow in the dark
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Glow in the dark

Loucas Christodoulou1, Kit Wu2

1Department of Paediatric Neurology, Chelsea and Westminster Hospital, London, UK; 2Department of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK

Correspondence to: Dr. Loucas Christodoulou, MD, MRCPCH, Specialist Registrar in Paediatrics. Department of Paediatric Neurology, Chelsea and Westminster Hospital NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, UK. Email: loucas@doctors.org.uk.

Objective: To highlight the importance of radiation safety and handling of radioactive secretions following 131I-meta iodobenzylguanidine (131I-mIBG) use in the treatment of neuroblastoma.

Methods: We report a 4-year-old girl with stage 4 neuroblastoma, on whom’s single-photon emission computer tomography (SPECT) scan we demonstrate four extra-corporal areas of radioactivity confirming radiation uptake in the four corners of her ‘comfort blanket’ that had been used to cover her during the scan. It transpired that she had been sucking on the four corners of this blanket.

Results: The patient’s secretions remain radioactive for some time following scintigraphy, as evidence of radioactivity in the patient’s comfort blanket.

Conclusions: Radioactive uptake of 131I-mIBG in the salivary glands of patients has previously been reported. This illustrative case emphasizes that patient’s secretions remain radioactive following treatment and highlights the importance of careful handling of radioactive secretions.

Keywords: 131I-meta iodobenzylguanidine (131I-mIBG); salivary uptake; radiation safety; neuroblastoma; SPECT scan

Submitted Oct 03, 2014. Accepted for publication Oct 15, 2014.

doi: 10.3978/j.issn.2223-4292.2014.11.29

Image of the month

A 4-year-old girl with stage 4 neuroblastoma had a single-photon emission computer tomography (SPECT) scan three days after a therapeutic administration of radioactive 131I-meta iodobenzylguanidine (131I-mIBG). Figure 1A illustrates four radioactive areas (see arrows) outside her body contours in addition to the radioactive uptake in the metastases. It transpired that the child had been sucking at the four corners of her ‘comfort blanket’ throughout her treatment, which had also been used to cover her during the scan, resulting in radioactive contamination of the corners of the blanket. The blanket was scanned separately, confirming the nature of external abnormalities (Figure 1B).

Figure 1 (A) Single-photon emission computer tomography (SPECT) scan three days after a therapeutic administration of radioactive 131I-meta iodobenzylguanidine (131I-mIBG) for neuroblastoma. Arrows point to four radioactive areas outside the body contours in addition to the radioactive uptake in the metastases; (B) scan of the child’s ‘comfort blanket’, showing radioactive contamination of the corners of the blanket from the child’s saliva.

Molecular radiotherapy with 131I-mIBG for neuroblastoma has been in clinical use for nearly 30 years. In this time, its role has changed from being an exclusively palliative treatment to one where the intent of treatment is often curative (1). Uptake of 131I-mIBG has been reported by Nakajo et al. in the salivary glands of patients undergoing scintigraphy for the location of suspected pheochromocytomas. This uptake of radioactivity was not due to free 131I derived from the 131I-mIBG but rather to uptake of 131I-mIBG by sympathetic neuronal elements in the salivary glands (2).

This illustrative case emphasizes that patient’s secretions remain radioactive for some time following treatment and highlights the importance of careful handling of radioactive secretions.

Disclosure: The authors declare no conflict of interest.

References

  1. Gaze MN, Gains JE, Walker C, Bomanji JB. Optimization of molecular radiotherapy with [131I]-meta Iodobenzylguanidine for high-risk neuroblastoma. Q J Nucl Med Mol Imaging 2013;57:66-78. [PubMed]
  2. Nakajo M, Shapiro B, Sisson JC, Swanson DP, Beierwaltes WH. Salivary gland accumulation of meta-[131I]iodobenzylguanidine. J Nucl Med 1984;25:2-6. [PubMed]
Cite this article as: Christodoulou L, Wu K. Glow in the dark. Quant Imaging Med Surg 2015;5(3):483-484. doi: 10.3978/j.issn.2223-4292.2014.11.29

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